avianinfluenza.org

Avian Influenza Human Vaccine Developments

Updated: Monday, January 20, 2020 10:35 AM EDT
Avian influenza Articles
Preparing for Human, H5N1 bird flu outbreak
Bird flu symptoms
Can you catch Bird Flu , Avian Influenza from eating poultry?
Confirmed human H5N1 bird flu cases
The origins of Bird Flu
Your cat and Bird flu , avian influenza
Potential bird flu treatment discovery
Bird flu , Avian influenza, new Spanish flu of 1918?
Bird Flu scare and the US bird Embargo
Bird flu , Avian Influenza a non-technical view
Bird flu , Avian flu outbreaks (human to human) in North America
Bird flu , Avian Influenza virus in Smuggled Thai Eagles
Bird flu , Avian Influenza Mutation H5N1 Virus
H5N1 Bird flu , Avian Influenza human vaccine developments
Bird flu , Avian influenza, fact or fiction?
Economic and Social Impacts of Bird Flu , Avian Influenza
Preparing For Pandemic Influenza
Bird Flu , Avian Influenza FAQ
Trial of Experimental Bird Flu , Avian Influenza Vaccine
Bird flu , Avian Influenza infection in Humans
Bird Flu , Avian Influenza explained

Bird Flu Map Links
USGS Interactive Bird flu map
Whooper Swan Tracking Map
Bird flu - US Government

H5N1 Avian Influenza, Bird Flu. Some developments for a human vaccine.

On August 6, 2005, government scientists at UNIAID, (US National Institute of Allergy and Infectious Diseases), announced results from the first clinical trials of a vaccine being developed to protect humans against H5N1 avian influenza ( bird Flu ). Preliminary tests show that the experimental vaccine evoked an immune response in a small group of healthy adults.

Although more tests are needed, this is at least a good sign that developing a H5N1 specific vaccine is possible.

Currently it is believed that the next pandemic will be caused by the H5N1, Avian Influenza ( bird flu ) virus. The increasing spread of the H5N1 virus, especially in asia, have brought the world much closer to to another pandemic then at any time since 1968, when the last of the 1900's three pandemics began.

Vaccines are the main ammunition in the fight against pandemic influenzas, especially ones of the Avian Influenza (bird flu) type. If available to the public in a timely manner and in great enough quanities they can reduce the morbidity and mortality that have traditionally made pandemics such socially disruptive as well as deadly events.

However many obstacles need to be overcome before vaccines can even help alleviate some of the effects of the next pandemic.One of, if not the most important is to find vaccine formulations that make the greatest use of the limited supply of antigens we have.

Antigen is the component of the vaccine that elicits an immune response. The US trial provides important insight into possible vaccine formulations. It used doses that are higher than the amount of virus antigen contained in influenza vaccines produced yearly for normal seasonal epidemics.

Strategies for stretching limited antigen supplies

By adding an adjuvant to the vaccine formulation or injecting the vaccine into the skin rather than into muscle, have been proposed. Adjuvants are chemicals that can be added to the vaccine formulation to boost the immune response, theoretically allowing the use of smaller doses of antigen to achieve an immune response. Such antigen-sparing strategies using adjuvants are currently being tested by several manufacturers, and preliminary results are expected within the next three months.

At present, 90% of production capacity for all influenza vaccines is concentrated in Europe and North America in countries that account for only 10% of the world’s population. Current global manufacturing capacity (estimated at 300 million doses of regular trivalent influenza vaccine per year) is inadequate to meet the expected global needs during a pandemic and cannot be rapidly augmented.

Influenza pandemics are unique infectious disease events that can spread to every country in the world within months, resulting in a high and universal demand for preventive and treatment measures. Pandemics thus throw into sharp relief inequities in global access to vaccines and other medical interventions during an emergency. Based on past experience, countries with local manufacturing capacity are likely to meet domestic demand for vaccines and other critical resources fully before freeing supplies for the export market.

Because the present total global manufacturing capacity for influenza vaccine is limited, any decision to manufacture a pandemic vaccine in large quantities prior to the start of a pandemic would, of necessity, compromise the capacity to produce vaccines for seasonal influenza. Seasonal epidemics of influenza predictably cause an estimated 250,000 to 500,000 deaths each year. In the current situation, the capacity to respond to seasonal influenza must be balanced against preparations for pandemic influenza. However, once a pandemic has been declared, all manufacturers would stop production of seasonal vaccines and produce only the pandemic vaccine.

Avian Influenza, Bird flu preparedness

In a nutshell this means that the world as a whole needs to prepare as if a pandemic was just around the corner. While H5N1, Avian influenza ( Bird Flu) may be the current worry in regards to a pandemic, it will not be the least or the last.

This article was adapted from articles from the World Health Organization as well as medical texts available on the web
Germany farm ministry confirms case of bird flu in wild bird - Reuters
20 Jan 2020 at 7:18am
Germany farm ministry confirms case of bird flu in wild bird - Reuters
20 Jan 2020 at 7:18am
Bird Flu Treatment Market 2021: Industry Growth, Competitive Analysis, Future...
20 Jan 2020 at 7:11am
Bird Flu Treatment Market 2021: Industry Growth, Competitive Analysis, Future...
20 Jan 2020 at 7:11am
Slovakia detects second case of H5N8 bird flu - Reuters
20 Jan 2020 at 6:47am
Slovakia detects second case of H5N8 bird flu - Reuters
20 Jan 2020 at 6:47am
China reports new H5N6 bird flu case in Xinjiang region - Reuters
20 Jan 2020 at 2:56am
China reports new H5N6 bird flu case in Xinjiang region - Reuters
20 Jan 2020 at 2:56am
Edinburgh-backed vaccine firm raises £680,000 to target ebola and bird flu - ...
20 Jan 2020 at 1:00am
Edinburgh-backed vaccine firm raises £680,000 to target ebola and bird flu - ...
20 Jan 2020 at 1:00am
Czech Republic Confirms First Ever Case of H5N8 Bird Flu after Three Years - ...
20 Jan 2020 at 12:45am
Czech Republic Confirms First Ever Case of H5N8 Bird Flu after Three Years - ...
20 Jan 2020 at 12:45am
Czechs detect bird flu as new Europe outbreak feared - Phys.org
18 Jan 2020 at 1:16pm
Czechs detect bird flu as new Europe outbreak feared - Phys.org
18 Jan 2020 at 1:16pm
Bird flu found among domestic birds in Poland - bnn-news.com
17 Jan 2020 at 10:18pm
Bird flu found among domestic birds in Poland - bnn-news.com
17 Jan 2020 at 10:18pm
UAE bans import of eggs, meat owing to bird flu, H5N2 outbreak - Daijiworld.com
16 Jan 2020 at 11:16pm
UAE bans import of eggs, meat owing to bird flu, H5N2 outbreak - Daijiworld.com
16 Jan 2020 at 11:16pm
China detects new case of H5N6 bird flu in Xinjiang region: ministry - Reuters
16 Jan 2020 at 3:46am
China detects new case of H5N6 bird flu in Xinjiang region: ministry - Reuters
16 Jan 2020 at 3:46am
Non-notifiable bird flu confirmed at NI poultry farm - FarmersWeekly
16 Jan 2020 at 2:38am
Non-notifiable bird flu confirmed at NI poultry farm - FarmersWeekly
16 Jan 2020 at 2:38am
H5N8 bird flu found in eastern Hungary - China Economic Net
15 Jan 2020 at 12:04pm
H5N8 bird flu found in eastern Hungary - China Economic Net
15 Jan 2020 at 12:04pm
Bird flu outbreak cause unknown: minister - Warsaw Business Journal
15 Jan 2020 at 8:45am
Bird flu outbreak cause unknown: minister - Warsaw Business Journal
15 Jan 2020 at 8:45am
Non-notifiable bird flu identified in Fermanagh - Irish Farmers Journal
15 Jan 2020 at 8:40am
Non-notifiable bird flu identified in Fermanagh - Irish Farmers Journal
15 Jan 2020 at 8:40am
Bird flu strain: UAE bans live birds, poultry and meat from Hungary and Slova...
15 Jan 2020 at 5:53am
Bird flu strain: UAE bans live birds, poultry and meat from Hungary and Slova...
15 Jan 2020 at 5:53am
Hundreds of Thousands of Poultry to be Killed as Bird Flu Hits Hungary - Hung...
15 Jan 2020 at 5:38am
Hundreds of Thousands of Poultry to be Killed as Bird Flu Hits Hungary - Hung...
15 Jan 2020 at 5:38am
Romania reports outbreak of H5N8 bird flu on a farm: OIE - Reuters
15 Jan 2020 at 2:38am
Romania reports outbreak of H5N8 bird flu on a farm: OIE - Reuters
15 Jan 2020 at 2:38am
Bird flu has been eliminated in Athelington zone 14 January 2020 - Zenopa
14 Jan 2020 at 10:37am
Bird flu has been eliminated in Athelington zone 14 January 2020 - Zenopa
14 Jan 2020 at 10:37am
Pirbright scientists develop bird flu and Marek's disease vaccine - Agriland....
14 Jan 2020 at 6:12am
Pirbright scientists develop bird flu and Marek's disease vaccine - Agriland....
14 Jan 2020 at 6:12am
Eat chicken: Newcastle virus, bird flu 'don't harm humans' - Dominican Today
14 Jan 2020 at 5:47am
Eat chicken: Newcastle virus, bird flu 'don't harm humans' - Dominican Today
14 Jan 2020 at 5:47am