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Avian Influenza Infection in Humans

Updated: Monday, December 17, 2018 5:09 AM EDT
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Avian Influenza Infection in Humans

Although avian influenza A viruses usually do not infect humans, more than 100 confirmed cases of human infection with avian influenza viruses have been reported since 1997. For example, the World Health Organization (WHO) maintains situation updates and cumulative reports of human cases of avian influenza A (H5N1). Most cases of avian influenza infection in humans are thought to have resulted from direct contact with infected poultry or contaminated surfaces. However, there is still a lot to learn about how different subtypes and strains of avian influenza virus might affect humans. For example, it is not known how the distinction between low pathogenic and highly pathogenic strains might impact the health risk to humans. (For more information, see “Low Pathogenic versus Highly Pathogenic Avian Influenza Viruses” on the CDC Influenza Viruses Web page.

Because of concerns about the potential for more widespread infection in the human population, public health authorities closely monitor outbreaks of human illness associated with avian influenza. To date, human infections with avian influenza A viruses detected since 1997 have not resulted in sustained human-to-human transmission. However, because influenza A viruses have the potential to change and gain the ability to spread easily between people, monitoring for human infection and person-to-person transmission is important.

Instances of Avian Influenza Infections in Humans

Confirmed instances of avian influenza viruses infecting humans since 1997 include:

Symptoms of Avian Influenza in Humans

The reported symptoms of avian influenza in humans have ranged from typical influenza-like symptoms (e.g., fever, cough, sore throat, and muscle aches) to eye infections (conjunctivitis), pneumonia, acute respiratory distress, viral pneumonia, and other severe and life-threatening complications.

Antiviral Agents for Influenza

Four different influenza antiviral drugs (amantadine, rimantadine, oseltamivir, and zanamivir) are approved by the U.S. Food and Drug Administration (FDA) for the treatment of influenza; three are approved for prophylaxis. All four have activity against influenza A viruses. However, sometimes influenza strains can become resistant to these drugs, and therefore the drugs may not always be effective. For example, analyses of some of the 2004 H5N1 viruses isolated from poultry and humans in Asia have shown that the viruses are resistant to two of the medications (amantadine and rimantadine). Monitoring of avian influenza A viruses for resistance to influenza antiviral medications is ongoing.

Odisha: Chicken price drops amid bird flu threat - The New Indian Express
16 Dec 2018 at 6:58pm
Odisha: Chicken price drops amid bird flu threat - The New Indian Express
16 Dec 2018 at 6:58pm
What's happening in Bird Flu Treatment Market 2018? - Journalists' Mail
16 Dec 2018 at 2:01pm
What's happening in Bird Flu Treatment Market 2018? - Journalists' Mail
16 Dec 2018 at 2:01pm
Minister: Bird flu causing egg price hike - Nation - The Star Online
15 Dec 2018 at 6:25pm
Minister: Bird flu causing egg price hike - Nation - The Star Online
15 Dec 2018 at 6:25pm
Bird Flu Outbreak: Mass culling continues for second day in Puri - Odisha Tel...
15 Dec 2018 at 11:23am
Bird Flu Outbreak: Mass culling continues for second day in Puri - Odisha Tel...
15 Dec 2018 at 11:23am
Import of birds and poultry from Russia suspended to avoid bird flu - The Tha...
15 Dec 2018 at 5:01am
Import of birds and poultry from Russia suspended to avoid bird flu - The Tha...
15 Dec 2018 at 5:01am
Culling Of Chickens Begins Near Chilika Lake After Bird Flu Hits Odisha - NDT...
14 Dec 2018 at 2:49pm
Culling Of Chickens Begins Near Chilika Lake After Bird Flu Hits Odisha - NDT...
14 Dec 2018 at 2:49pm
Bird flu alert sounded at the fringes of Bhitarkanika National Park - OrissaPOST
14 Dec 2018 at 12:40am
Bird flu alert sounded at the fringes of Bhitarkanika National Park - OrissaPOST
14 Dec 2018 at 12:40am
Odisha Bird flu: Government orders culling in four Puri villages from today -...
13 Dec 2018 at 7:27pm
Odisha Bird flu: Government orders culling in four Puri villages from today -...
13 Dec 2018 at 7:27pm
40,000 chickens put down on Powellville farm due to bird flu fears - Delmarva...
13 Dec 2018 at 3:33pm
40,000 chickens put down on Powellville farm due to bird flu fears - Delmarva...
13 Dec 2018 at 3:33pm
ADRI team to visit Chilika Lake to inspect bird flu - Pragativadi
13 Dec 2018 at 1:41pm
ADRI team to visit Chilika Lake to inspect bird flu - Pragativadi
13 Dec 2018 at 1:41pm
Traveler caught smuggling 70 live birds hidden in hair rollers into US - NBC2...
13 Dec 2018 at 12:49pm
Traveler caught smuggling 70 live birds hidden in hair rollers into US - NBC2...
13 Dec 2018 at 12:49pm
Bird flu: Odisha govt orders culling of chicken in 4 villages in Puri - Times...
13 Dec 2018 at 5:46am
Bird flu: Odisha govt orders culling of chicken in 4 villages in Puri - Times...
13 Dec 2018 at 5:46am
Taking steps to prevent bird flu outbreak on poultry farms - Guardian Nigeria
12 Dec 2018 at 8:14pm
Taking steps to prevent bird flu outbreak on poultry farms - Guardian Nigeria
12 Dec 2018 at 8:14pm
No new cases of H5N1 bird flu in humans reported since 2014 - Viet Nam News
11 Dec 2018 at 7:00pm
No new cases of H5N1 bird flu in humans reported since 2014 - Viet Nam News
11 Dec 2018 at 7:00pm
Bird flu alert in Odisha's Bhitarkanika National Park - The New Indian Express
11 Dec 2018 at 6:38pm
Bird flu alert in Odisha's Bhitarkanika National Park - The New Indian Express
11 Dec 2018 at 6:38pm
Bird flu scare grips Puri villages after death of many birds - OrissaPOST
9 Dec 2018 at 12:13am
Bird flu scare grips Puri villages after death of many birds - OrissaPOST
9 Dec 2018 at 12:13am
Bird flu strain could overcome vaccines and infect humans, scientists warn - ...
6 Dec 2018 at 5:00am
Bird flu strain could overcome vaccines and infect humans, scientists warn - ...
6 Dec 2018 at 5:00am
H5N8 Bird Flu Reported Near Tehran - Financial Tribune
4 Dec 2018 at 1:00am
H5N8 Bird Flu Reported Near Tehran - Financial Tribune
4 Dec 2018 at 1:00am
Iran reports H5N8 bird flu in backyard poultry - OIE - Reuters
3 Dec 2018 at 6:50am
Iran reports H5N8 bird flu in backyard poultry - OIE - Reuters
3 Dec 2018 at 6:50am
Avian Bird Flu winter warning - The Scottish Farmer
2 Dec 2018 at 1:00am
Avian Bird Flu winter warning - The Scottish Farmer
2 Dec 2018 at 1:00am